A Comprehensive Assessment of Lung Structure and Function via Dynamic, Volumetric X-ray CT

8/25/99


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Table of Contents

A Comprehensive Assessment of Lung Structure and Function via Dynamic, Volumetric X-ray CT

Overview

Measures Included in a Comprehensive Assessment of the Lung

EBCT/Multislice Helical

Lung Volume Controller to assure standardization of lung inflation during scan

Stable Xenon Gas as a CT Contrast Agent for the Assessment of Regional Ventilation

Multi-breath Washout Subtraction Images

Repeatability of Tracer Clearance Data

Flow Rate Dependence : Increased Role of Conductance with Increased Inspiratory Flow Rate

Single Breath Protocol With Prolonged Apnea For Use with Helical CT: Instability of Dependent Lung Density

Pulmonary Blood Flow

Distribution of PBF (ml/gm/min)

System Description: Bolus Injection, Residue Detection

Filtered FFT Deconvolution w/ Inverted Hanning Window

Deconvolution-Based Microvascular Microvascular Mean Transit Times

Adaptive Multiple Feature Method (AMFM)

Baysian Classifier

Anterior-Posterior differences

Global - Normal vs. IPF

Global - IPF vs. Sarcoidosis

Regional analysis

Observer validation scheme

Three readings by example reader for an emphysema slice

Validation results third session

Non-smokers-Smokers-COPD

Standard For Mapping Function to Structure

CT-Based Normal Human Lung Model

Author: Eric A. Hoffman Ph.D.

Email: eric-hoffman@uiowa.edu

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