Heart Lung Interaction/ Lessons From Volumetric Imaging
Early Videodensitometric Analysis
In search of true ventricular geometry
DSR Arrives 1979
DSR Geometry Volumetric Scanning
EBCT Geometry Multiple Single Slices
In Plane vs Through Plane Resolution
Advantage of Volumetric Imaging: Detailed Cardiac Geometry
Reconstruction of Beating Heart
Myocardial Volume Measurement Achieved
Early Observation from Dogs Breathing Liquid Fluorocarbon:
Total Heart Volume Relationship
Quantitation of Total Heart Volume
Less Than 5% Variation Throughout Cycle
Fixed Apex and Piston Motion of Valve Plane
Reciprocal Emptying of Atria and Ventricles
Applicability to Humans: MRI Scanning
Verification: Constant Heart Volume in Humans
Cardiac Tagging: Wringing of Ventricle
Verification of Fixed Apex and Valve Plane Motion
Loss of CHV in Atrial Fibrilation
Loss of Valve Plane Motion
Increased Work during AF
Increased MBF In AF
Myocardial Blood Flow by EBCT
Heart Lung Interaction
Evidence for non-gravitational influences contributing to heterogeneity of lung air content
Pattern of Regional Lung Air Content Mapped to Lung Surface
Pattern of Regional Lung Air Content Mapped to Lung Surface cont.
EBCT: Distribution of PBF (ml / gm / min)
REGIONAL PULMONARY BLOOD-AIR VOLUME RELATIONSHIP
Cardiogenic Motion of Lung Parenchyma: Effect on Image Resolution
Static Positive Pressure Lung Inflation (DSR)
Cardiac Gated Ventilation
Systolic Cardiac-Gated Ventilation Provides Cardiac Assist
Respiratory Phase 3, Late-Systole: Cardiac Slices Base-to-Apex, Sample ROI
Cardiac Dynamics via Echo-planar MR Scanning: “Progressive Delay”
Heart-lung Interaction: MR Scanning Protocol
Respiration Effect on Diastole
Respiratory Effect on Systole
Hypothesis
Systolic Cardiac-Gated Ventilation (EBCT): Effect on Regional Pulmonary Blood Flow
The Future: 2-D Array Detector for 4D EBCT
Email: eric-hoffman@uiowa.edu
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